Last Array of Hope - COVID-19 Convalescent Plasma Therapy

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A pilot trial of convalescent plasma treatment in 10 extreme COVID-19 patients has indicated it might be a protected and promising helpful choice. M ore than fifteen Indian states and Union Territories represent over 95% of the total coronavirus cases in the nation. Amongst them, 33% of the  cases are reported in Maharashtra and Tamil Nadu, which are speeding up lately. Economic times surveys the information, which recommends that a portion of the 15 states/UTs need to put forth a more noteworthy attempt to flatten the curve. Source: WWW.MoHFW.gov Coronavirus disease is an infectious pneumonia-related severe respiratory illness. The official name, Coronavirus disease 2019 which is also called COVID-19 was given by the world health organization (WHO), and the first case of this disease was reported in Wuhan, China.  The scourge spread quickly all around the world within 3 months and has been declared as a pandemic by WHO on March 11, 2020. As of April 13...
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Several Genes- A Threat of Mental Health

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The origins of the violent behaviour are multifactorial and respond to the interaction of several factors -- biological, cultural, social, etc. -- which can modify the expression of the human behaviour. Which is followed by  international study published in the journal Molecular Psychiatry has identified forty genes related to aggressive behaviour in humans and mice.

Aggressive behaviour is a present feature over the biological evolution since it has some benefits for the survival of species (accessing resources, breeding, etc.). As we know aggressiveness has a significant environmental element like combine genetic and environmental data from the same individuals to consider the interactions that can occur between the same risk factors that influence aggresive behavior"
        According to study Humans and mice share a common genetic base regarding violent behaviour, There are some identified forty genes in humans and mice that can lead to a risk of aggressive behaviours "and that take part in biological processes are related to the development and function of the central nervous system, communication within cells and cellular function maintenance, " adds researcher Fernàndez Castillo (IBUB-CIBERER-IRSJD). "Some genes are likely to function as important nodes of the genetic networks prone to a violent behaviour, and those would be probably related to other genes which play a minor role," adds the researcher.
       "If any of those central genes is altered, it could affect the other genes and lead to the aggressive phenotype. For instance, RBFOX1 gene, identified in the new study and cited in a previous article by European Neuropsychopharmacology, 2017 , Which regulates the expression of fifteen out of the forty genes that identified in the study. Another gene marked as  -MAOA, which codes a metabolizing enzyme of the serotonin neurotransmission-, is related to drugs used to treat several psychiatric pathologies, sycg as selective inhibitors of serotonin reuptake or SSRIs."
   
Violent Behavio from ADHD to major depression
        An international study published in the journal Molecular Psychiatry reveals a shared genetic base between the aggressiveness in children and adults and the Attention Deficit Hyperactivity Disorder (ADHD), and the aggressiveness in adults and major depression. However, there is no genetic correlation with other psychiatric disorders -schizophrenia, bipolar disorder, autism or post-traumatic stress disorder-, so everything suggests these pathologies would not share risk genetic factors with aggressiveness.
     So there is a several study like in murine models, researchers studied genes expressed differentially in aggressive animals and non-aggressive animals from the same strain, and other genes that, once they are inactive -in transgenic mice-, form an aggressive phenotype, sometimes related to a broader symptomatology.
      Working globally on the involved functional pathways in violent behaviours enabled researchers knowing more about the details of the molecular mechanisms that work behind aggressiveness. "The most relevant verification of the study is that many genes are related to aggressiveness according to the results of very different experimental methodologies, which strengthens the idea of those participating in the behaviour profile," highlight Cormand and Fernàndez Castillo, members of the international multidiscipline consortium Aggressotype for the study of biological and environmental causes of aggressiveness.
      There are so many experts have published several articles which shaping regarding this topic in several animals.

Violence: government, communities, and individuals can change the situation worldwide

      "The 20st century will be remembered as the century of violence. Many people live with it daily and regard it as something consubstantial to the human condition, but it is not so. We can avoid it. Governments, communities and individuals can change the situation," said Nelson Mandela, politician and Nobel Peace Prize awardee in 1993, in the world report on violence and health of the World Health Organization (WHO, 2002). In 2014, the WHO report on the world situation regarding prevention of violence quoted Nelson Mandela's words and called all countries to improve preventive measures against violent behaviors. In this world scenario, facing a problem that affects all the layers of society, scientific research will become more and more important in the knowledge of the basis of antisocial behaviors and the improvement of the prevention of episodes of violence and aggressiveness in the 21st century society.

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